Response by Spaander et al to Letter Regarding Article, "Sex Differences and Functional Outcome After Intravenous Thrombolysis".
نویسندگان
چکیده
BACKGROUND AND PURPOSE Women have a worse outcome after stroke compared with men, although in intravenous thrombolysis (IVT)-treated patients, women seem to benefit more. Besides sex differences, age has also a possible effect on functional outcome. The interaction of sex on the functional outcome in IVT-treated patients in relation to age remains complex. The purpose of this study was to compare outcome after IVT between women and men with regard to age in a large multicenter European cohort reflecting daily clinical practice of acute stroke care. METHODS Data were obtained from IVT registries of 12 European tertiary hospitals. The primary outcome was poor functional outcome, defined as a modified Rankin scale score of 3 to 6 at 3 months. We stratified outcome by age in decades. Safety measures were symptomatic intracranial hemorrhage and mortality at 3 months. RESULTS In this cohort, 9495 patients were treated with IVT, and 4170 (43.9%) were women with a mean age of 71.9 years. After adjustments for baseline differences, female sex remained associated with poor functional outcome (odds ratio, 1.15; 95% confidence interval, 1.02-1.31). There was no association between sex and functional outcome when data were stratified by age. Symptomatic intracranial hemorrhage rate was similar in both sexes (adjusted odds ratio, 0.93; 95% confidence interval, 0.73-1.19), whereas mortality was lower among women (adjusted odds ratio, 0.83; 95% confidence interval, 0.70-0.99). CONCLUSIONS In this large cohort of IVT-treated patients, women more often had poor functional outcome compared with men. This difference was not dependent on age.
منابع مشابه
Correction to: Sex Differences and Functional Outcome After Intravenous Thrombolysis.
In the article by Spaander et al, “‘Sex Differences and Functional Outcome After Intravenous Thrombolysis,” which published online ahead of print January 31, 2017, and appeared in the March 2017 issue of the journal (Stroke. 2017;48:699–703. DOI: 10.1161/STROKEAHA.116.014739), a correction is needed. On page 699, in the title, “‘Sex Differences and Functional Outcome After Intravenous Thromboly...
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متن کاملSex Differences and Functional Outcome After Intravenous Thrombolysis
There is a growing recognition of importance of sex in stroke outcome. More women are affected by stroke because of their longer life expectancy and have a worse functional outcome and a lower quality of life after stroke compared with men. In patients with acute stroke, previous research has also shown sex to affect outcome after intravenous thrombolysis (IVT) treatment; although outcome was s...
متن کاملLetter by Scheitz et al regarding article, "Intravenous thrombolysis in nonagenarians with ischemic stroke".
متن کامل
Does sex influence the response to intravenous thrombolysis in ischemic stroke?: answers from safe implementation of treatments in Stroke-International Stroke Thrombolysis Register.
BACKGROUND AND PURPOSE Women are more likely to have a worse outcome after an acute stroke than men. Some studies have suggested that women also benefit less from intravenous thrombolysis after an acute ischemic stroke, but others found no sex differences in safety and efficacy. We aimed to evaluate differences in 3-month outcome between sexes in intravenous tissue-type plasminogen activator-tr...
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عنوان ژورنال:
- Stroke
دوره 48 7 شماره
صفحات -
تاریخ انتشار 2017